A palazzo designed in 1432 by Filippo Brunelleschi, the architect of the Duomo Santa Maria del Fiore, The St. Regis Florence was converted into a hotel in the mid-1800s. When Queen Victoria took a Grand Tour, she stayed here. Now there’s a designer suite by Italian luxury fashion house Bottega Veneta, and the hotel spa is collaborating with luxury cosmetics brand My Blend by Clarins. The Winter Garden by Caino restaurant, where guests can enjoy gourmet cuisine created in collaboration with two-Michelin-starred chef Valeria Piccini, has a 19th-century illuminated colored-glass ceiling; and in keeping with the Tuscan capital’s Renaissance heritage, there are classic frescoes and antiques throughout the building. Florence is a compact and, in the right season, relaxing city. After you’ve seen the world-class Uffizi Gallery and Michelangelo’s David in the Accademia, make the most of the hotel’s location on the Piazza Ognissanti in the city’s historical heart: order an aperitivo, and sit back and watch as dusk falls over the city’s churches, hills and bell towers.